| Cyclodextrins (CyDs) are high-performance drug carriers, because of their ability to control rate and time profiles of drug release, the ability to enhance the drug absorption across biological barriers, and the ability to deliver a drug to a targeted site. We are currently engaging in the research projects entitle “Design and Evaluation of CyD-based Drug Delivery Systems (DDS)” as follows: 1) Improvement of pharmaceutical properties of various drugs based on the inclusion complex formation with CyD, 2) Development of cyclodextrin derivatives as active pharmaceutical ingredients, 3) Tumor-selective anticancer drug delivery using folate-appended CyDs, 4) Design and evaluation of molecular neckless such as CyD polypseudoroxanes and polycatenanes as novel pharmaceutical materials, 5) Development of nucleic acids carriers and enhancement of genome editing efficacy using novel conjugates of cationic polymers with CyDs, and 6) Application of CyD derivatives as adjuvants for activation of immune responses. |
